Here's something I recently made featuring Frankenstein's 80s Monster I've been slowly creating (ITS ALIVE! ALIIIIVEEEE!), who is holding 'Sparks', his favorite cat companion. He's also wearing a nifty sweater to keep himself warm, because his circulation isn't so great. Being pieced together from parts is hard to get right!
I used a multilayered process. I started with an inked pencil sketch from my Moleskine, then scanned and vectorized my lines in Illustrator. After that I threw a high res PNG over to my iPad and colored it in Pixelmator, using 52's Pencil. Finishing involved adding textures and lights in Mextures.
Maybe one day he'll be a painting but for now he's ink and digital color. I think he's a good candidate for a tshirt graphic! What do you think?